How it Works:

• Ofloxacin is a fluoroquinolone that has a broad spectrum of activity against otic pathogens but lacks the capacity for ototoxicity. Hence ofloxacin is preferred to aminoglycosides for any application within the middle ear space. Ofloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial enzyme that is essential in DNA replication, repair, deactivation and transcription.
• Clotrimazole is a synthetic imidazole derivative. Clotrimazole is a broad-spectrum antifungal agent that has fungicidal activity against fungi responsible for superficial mycotic infections affecting the outer or middle ear including Candida, Microsporum, Trichophyton. Clotrimazole inhibits fungal cytochrome P-450 synthesis of ergosterol, which decreases fungal cell wall integrity. By inhibiting the biosynthesis of ergosterol for fungal cytoplasmic membrane, clotrimazole inhibits fungal growth. Resistance to clotrimazole is very rare among the fungi that cause superficial mycoses.Clotrimazole also has activity against certain gram-positive bacteria such as Streptococci and Staphylococci. It is the most widely used topical azole. Its antibacterial effect is advantageous in treating mixed bacterial-fungal infections.
• Beclomethasone is a glucocorticoid steroid with anti inflammatory and immunosuppressive abilities.
• Lignocaine Hydrochloride is a topical anesthetic with a low index of sensitization and toxicity. It helps reduce pain and stinging in the ear.
• Otikoo Ear Drops by virtue of its three active ingredients, ofloxacin, clotrimazole, and beclomethasone, has antibacterial, antifungal and anti-inflammatory activity.

Dosage:

Administer 8 - 10 drops in each ear or as directed by the veterinarian

Precautions :

• For animal use only
• Not for human use